Princess Mononoke

While defending his village from a demonic boar-god, the young warrior Ashitaka becomes afflicted with a curse that grants him super-human power in battle but will eventually take his life. Traveling west to find a cure, he journeys deep into sacred depths of the Great Forest where he meets San (Princess Mononoke), a girl raised by wolf-gods who is waging battle against the human outpost of Iron Town.  

In Japanese with English Subtitles.